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Protease Inhibitors (PIs)
Drug
Adult Dosing
Possible Side Effects
Notes
Aptivus (tipranavir), by
Boehringer Ingelheim
Two 250mg capsules plus two 100mg
Norvir capsules, twice a day (a total of ...
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- Sunday, March 8, 2009, 20:24
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What is hydroxyurea?
Hydroxyurea is approved as an antineoplastic. Antineoplastics are used to treat cancer. Hydroxyurea is used to treat melanoma (a type of skin cancer), chronic myelocytic leukemia (CML), cancer of the ovary, and primary squamous cell (skin) cancer of the head and neck.
Hydroxyurea has also bee studied as a potential treatment for HIV infection. Although it is not approved by the U.S. ...
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- Sunday, March 8, 2009, 20:23
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What is Bevirimat?
Bevirimat is an anti-HIV medication. It is in a new category of HIV medicines known as maturation inhibitors.
Bevirimat is a derivative of a Chinese herb called Syzigium claviflorum.
Virus maturation is the process that occurs during the last stages of HIV reproduction, after the virus has been released from the infected cell. It involves the processing of viral proteins and is required for the ...
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- Sunday, March 8, 2009, 20:19
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What is elvitegravir?
Elvitegravir is an experimental integrase inhibitor being developed by Gilead Sciences.
After HIV's genetic material is deposited inside a cell, its RNA must be converted (reverse transcribed) into DNA. A viral enzyme called integrase then helps to hide HIV's DNA inside the cell's DNA. Once this happens, the cell can begin producing ...
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- Sunday, March 8, 2009, 20:14
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What is Isentress?
Isentress is an integrase inhibitor manufactured by Merck & Company. It was approved by the U.S. Food and Drug Administration (FDA) in October 2007. Isentress is approved for treatment-experienced patients who have HIV strains that are
resistant to multiple antiretroviral drugs. It is not yet approved for ...
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- Sunday, March 8, 2009, 20:10
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What is PRO 140?
PRO 140 is an experimental
entry inhibitor being developed by Progenics Pharmaceuticals, Inc. It has not yet been evaluated by the U.S. Food and Drug Administration (FDA) for use by people living with HIV.
PRO 140 contains genetically engineered antibodies, known as monoclonal antibodies. These antibodies bind to the CCR5 coreceptor on
CD4 cells (T cells). Once they ...
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- Sunday, March 8, 2009, 20:09
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What is ibalizumab?
Ibalizumab is an experimental
entry inhibitor being developed by Taimed Biologics. It has not yet been evaluated by the U.S. Food and Drug Administration (FDA) for use by people living with HIV.
Ibalizumab contains genetically engineered antibodies, known as monoclonal antibodies. These antibodies bind to the CD4 receptor on T-cells. Once ibalizumab binds to these receptors, HIV cannot successfully connect with the surface ...
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- Sunday, March 8, 2009, 20:07
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What is vicriviroc?
Vicriviroc is an experimental
entry inhibitor developed by the Schering-Plough Research Institute. Vicriviroc is also sometimes called SCH-D, its former code name.
Vicriviroc binds to a protein on the membrane of T-cells called CCR5. Once it does this, HIV cannot successfully bind with the surface of T-cells, thus preventing the virus from infecting healthy cells.
Vicriviroc is believed to be more ...
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- Sunday, March 8, 2009, 20:04
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What is Selzentry?
Selzentry is a CCR5-blocking
entry inhibitor manufactured by Pfizer. It was approved by the U.S. Food and Drug Administration (FDA) in August 2007. Selzentry is approved for treatment-experienced people who have HIV strains that are
resistant to multiple antiretroviral drugs. It is not yet approved for people with drug-sensitive ...
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- Sunday, March 8, 2009, 20:00
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What is the most important information I should know about Fuzeon?
Fuzeon is a fusion inhibitor being manufactured by Trimeris and Hoffmann-La Roche. It was approved by the U.S. Food and Drug Administration (FDA) in March, 2003. Fuzeon is approved for HIV-positive people who have tried other anti-HIV drugs in the ...
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